Our research in electroceuticals focuses on noninvasive neuromodulation strategies to precisely regulate neural circuits and autonomic function. We researched transcutaneous auricular vagus nerve stimulation (taVNS) and found that it induces autonomic modulation and produces antiepileptic effects in preclinical seizure models while significantly influencing heart rate variability (HRV) and electroencephalography (EEG) parameters in human studies. By integrating real-time physiological monitoring with adaptive signal processing, our lab is developing personalized neuromodulation therapies targeting epilepsy, hypertension, and autonomic dysfunction.

Our lab leads the development of bioelectronic implants by engineering long-term neuromodulation platforms using biocompatible materials and miniaturized electronics. We are pioneering expandable implantable bioelectronic systems that enable real-time sensing and modulation of neural activity. By integrating advanced materials science, electronics, and biomedical engineering, our work strives to deliver next-generation neuromodulation therapies. Our goal is to enhance the quality of life for patients suffering from chronic and refractory disorders through innovative and personalized medical solutions.

Our neuromodulation research explores both invasive and noninvasive techniques to recalibrate neural activity for therapeutic applications. We investigate Deep Brain Stimulation (DBS), Tibial Nerve Stimulation (TNS), Vagus Nerve Stimulation (VNS), and transcutaneous auricular VNS (taVNS), uncovering frequency-dependent modulation of autonomic and central nervous system activity. Notably, our research has characterized the temporal dynamics of the antihypertensive effects of auricular VNS and its potential role in seizure control. By leveraging advanced electrophysiological analysis and closed-loop stimulation paradigms, we integrate neuroscience and bioengineering to develop next-generation, personalized neuromodulation therapies for epilepsy, overactive bladder, chronic pain, and cardiovascular disorders.

신경인성 방광 환자에서 다채널 간섭 전기장 기반 비침습적 방광 자극을 통한 저활동성 방광 완화 기술 연구
ㆍ지원기관: 보건복지부 (보건산업진흥원)
ㆍ사업명:  임상현장수요연계형중개연구
ㆍ연구기간: 2025.05 ~ 2027.12
ㆍ총연구비: 794,200천원

배뇨 신경 메커니즘 해석 기반 디지털 트윈을 이용한 배뇨장애 치료 기술 개발
ㆍ지원기관: 과학기술정보통신부(한국연구재단)
ㆍ사업명:  중견연구자지원사업
ㆍ연구기간: 2023.09 ~ 2026.02
ㆍ총연구비: 671,093천원

장기간 배뇨질환 관리 및 근원적 치료를 위한 완전 이식형, 체내 기관 일체형 전자약 플랫폼 개발
ㆍ지원기관: 과학기술정보통신부 (한국연구재단)
ㆍ사업명:  전자약기술개발사업
ㆍ연구기간: 2023.04 ~ 2025.12
ㆍ총연구비: 825,000천원 (195,000천원)

난치성 배뇨장애 치료를 위한 피드백 기반의 배뇨기능 제어 기술 개발
ㆍ지원기관: 과학기술정보통신부 (한국연구재단) 
ㆍ사업명: 중견연구자지원사업
ㆍ연구기간: 2019.06 ~ 2023. 08

실시간 방광 활동 모니터링 및 다인성 배뇨장애 치료를 위한 신축ㆍ유연 소재 및 전자 시스템
ㆍ지원기관: (재)범부처전주기의료기기연구개발사업단
ㆍ사업명:  범부처전주기의료기기연구개발사업
ㆍ연구기간: 2020.09 ~ 2022.12